Adenoid cystic carcinoma
Definition
Adenoid cystic carcinoma is one of the common salivary gland malignancy. Because of its distinctive histopathologic features, it was originally called a "cylindroma”. The use of the term cylindroma should be avoided because it does not denote the malignant nature of the tumor and because the same term is used for a benign skin tumor. Clinical features
The adenoid cystic carcinoma can occur in any salivary gland site, but it occurs most commonly in the minor salivary gland.
The palate is the most common site.
It appears as a slowly growing mass.
Pain is a common and important finding, and may occur early in the course of the disease (due to perineural invasion).
Facial nerve paralysis (if the neoplasm affects the parotid).
Palatal tumors often are ulcerated.
Histogenesis
Adenoid Cystic Carcinoma originate from intercalated duct cells and myoepithelial cells.
Histopathologic features
The adenoid cystic carcinoma is composed of a mixture of myoepithelial cells and ductal cells.
The ductal cells are small and cuboidal, with deeply basophilic nuclei and little cytoplasm.
Myoepithelial cells have clear cytoplasm and darkly staining angular nuclei.
Three histopathologic patterns are recognized:
(1) cribriform , (2) tubular, and (3) solid.
(1) Cribriform pattern
Is the most common pattern.
It is characterized by islands of basaloid epithelial cells that contain multiple cystic spaces resembling swiss cheese.
These spaces often contain basophilic mucoid material.
(2) Tubular pattern
The tumor cells occur as multiple small ducts or tubules within a hyalinized stroma.
The duct like spaces are lined by an inner row of cuboidal epithelial cells and an outer zone of myoepithelial cells.
(3) Solid pattern
It consists of large islands or sheets of cuboidal epithelial cells.
This type may also show more pleomorphism and mitotic activity than the other forms.
This type is the most aggressive type.
HOW I GOT CURED OF HERPES VIRUS.
ReplyDeleteHello everyone out there, i am here to give my testimony about a herbalist called dr imoloa. i was infected with herpes simplex virus 2 in 2013, i went to many hospitals for cure but there was no solution, so i was thinking on how i can get a solution out so that my body can be okay. one day i was in the pool side browsing and thinking of where i can get a solution. i go through many website were i saw so many testimonies about dr imoloa on how he cured them. i did not believe but i decided to give him a try, i contacted him and he prepared the herpes for me which i received through DHL courier service. i took it for two weeks after then he instructed me to go for check up, after the test i was confirmed herpes negative. am so free and happy. so, if you have problem or you are infected with any disease kindly contact him on email drimolaherbalmademedicine@gmail.com. or / whatssapp --+2347081986098.
This testimony serve as an expression of my gratitude. he also have
herbal cure for, FEVER, DIARRHOEA, MOUTH ULCER, MOUTH CANCER FATIGUE, MUSCLE ACHES, LUPUS, SKIN CANCER, PENILE CANCER, BREAST CANCER, PANCREATIC CANCER, DISEASE, JOINT PAIN, POLIO DISEASE, PARKINSON'S DISEASE, ALZHEIMER'S DISEASE, CYSTIC FIBROSIS, SCHIZOPHRENIA, CORNEAL ULCER, EPILEPSY, FETAL ALCOHOL SPECTRUM, LICHEN PLANUS, COLD SORE, SHINGLES, CANCER, HEPATITIS A, B. DIABETES 1/2, HIV/AIDS, CHRONIC PANCERATIC, CHLAMYDIA, ZIKA VIRUS, EMPHYSEMA, LOW SPERM COUNT, ENZYMA, DRY COUGH, ARTHRITIS, LEUKAEMIA, LYME DISEASE, ASTHMA, IMPOTENCE, BARENESS/INFERTILITY, WEAK ERECTION, PENIS ENLARGEMENT. AND SO ON.