Oncocytoma
Oncocytoma is a benign salivary gland tumor composed of large epithelial cells known as oncocytes.
Oncocytes occur as a result of focal oncocytic metaplasia of salivary ductal and acinar cells which is a common finding in old age (above 50 years).
Histogenesis
It originates from oncocytes.
Clinical features
It is a tumor of old age (after the 6th decade of life).
More common in the major salivary glands especially the parotid gland.
It appears as a , slowly growing, painless, movable mass that rarely exceeds 4 cm in diameter.
Histopathologic features
It is a well-circumscribed tumor that is composed of sheets of large polyhedral cells (oncocytes),
The cells have granular eosinophilic cytoplasm with centrally located nuclei.
(The granular cytoplasm is due to excessive accumulation of mitochondria).
activity.
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